Formulation and Optimization of Nanosuspensions for Enhancing Simvastatin Dissolution Using Central Composite Design
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چکیده
منابع مشابه
Formulation and Optimization of Nanosuspensions for Enhancing Simvastatin Dissolution Using Central Composite Design
Simvastatin is a poorly water-soluble drug, and bioavailability from its crystalline form is very low. The purpose of this investigation was to increase the solubility and dissolution rate of simvastatin by the preparation of nanosuspensions with Pluronic F127 and zirconium oxide (ZrO2) beads using a wet-milling technique at the laboratory scale. Prepared nanosuspensions were evaluated for part...
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ژورنال
عنوان ژورنال: Dissolution Technologies
سال: 2011
ISSN: 1521-298X
DOI: 10.14227/dt180311p40